Water → 5,6-Dichloro-1,3-Dihydro-2H-Benzimidazol-2-One

HRID 408674

反応式

HRID 408674 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:10])[C:5]([NH2:9])=[CH:6][C:7]=1[Cl:8].O.CN([CH:15]=[O:16])C>>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]2[NH:9][C:15](=[O:16])[NH:10][C:4]=2[CH:3]=1

参加物

4

反応物 3

HCID 962WaterHCID 6228DimethylformamideHCID 792974,5-Dichloro-1,2-phenylenediamine

生成物 1

HCID 98991485,6-Dichloro-1,3-Dihydro-2H-Benzimidazol-2-One収率 90%

実験手順

To the solution of 4,5-dichloro-benzene-1,2-diamine (25 g, 0.14 mol) in dry DMF (200 mL), was added CU (23 g, 0.14 mol) as the solid. The reaction solution was stirred at room temperature for 1 hour, then water (500 mL) was added. The precipitated solid was collected by filtration, washed with water, dried thoroughly to afford the titled compound (26.0 g, 90%). The crude product was used in the following reaction without further purification.

後処理

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with water
  3. customdried thoroughly

出典と根拠

ORDレコード
ord-32e380d95b384ff68651510f7cc8c2b2
出典データセット
uspto-grants-2014_06
特許番号
US08759345B2

関連ノート

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