関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 4-Bromo-2,5-difluoronitrobenzene | HCID 2736286 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 5-Bromo-4-fluoro-2-nitroaniline | HCID 66937251 | — |
反応手順
A mixture of 1-bromo-2,5-difluoro-4-nitro-benzene (1.50 g, 6.30 mmol) and 7M ammonia in methanol (25 mL) was heated in a sealed tube at 60° C. for 15 h. The reaction mixture was transferred to a round bottom flask, washing the sealed tube with EtOAc. The reaction mixture was concentrated, and the crude material was used in the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08759345B2 |
|---|
| 出典データセット | uspto-grants-2014_06 |
|---|
| ORD ID | ord-58306cd599c14be59297b4ae57f9a0c7 |
|---|
| 出典メモ | uspto-grants-2014_06 |
|---|
