Hydrochloric Acid → 1-(2-Fluoroethyl)piperazine dihydrochloride

HRID 408812ノート

反応式

HRID 408812 の反応式
[ClH:1].O1CCOCC1.C(OC([N:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][F:23])[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[ClH:1].[ClH:1].[F:23][CH2:22][CH2:21][N:18]1[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 21082715tert-Butyl 4-(2-fluoroethyl)piperazine-1-carboxylate

生成物 1

HCID 665456881-(2-Fluoroethyl)piperazine dihydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Add 4 N HCl in 1,4-dioxane (21.52 mL, 86.1 mmol) to a stirred solution of 4-(2-fluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (2.00 g, 8.61 mmol) in dry dichloromethane (60 mL) at room temperature under nitrogen. Stir overnight under nitrogen. Concentrate the reaction under reduced pressure to afford the title compound (1.78 g). ES/MS m/z 133 (M+1).

後処理

  1. concentrationConcentrate
  2. customthe reaction under reduced pressure

出典と根拠

ORDレコード
ord-1cfc899297914db39f4a9a1200e8a672
出典データセット
uspto-grants-2014_06
特許番号
US08759360B2

反応ノート

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