Cyclopropanemethanamine → Ethyl 4-(3-(cyclopropylmethyl)ureido)benzoate

HRID 408861ノート

反応式

HRID 408861 の反応式
[CH:1]1([CH2:4][NH2:5])[CH2:3][CH2:2]1.[N:6]([C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:11][CH:10]=1)=[C:7]=[O:8]>ClCCl>[CH:1]1([CH2:4][NH:5][C:7](=[O:8])[NH:6][C:9]2[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:11][CH:10]=2)[CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 75646CyclopropanemethanamineHCID 589805Ethyl 4-isocyanatobenzoate

生成物 1

HCID 3830959Ethyl 4-(3-(cyclopropylmethyl)ureido)benzoate収率 107.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To cyclopropylmethanamine (57.5 mmol, 4.99 ml, 4.09 g) in dichloromethane (40 mL) was added to ethyl 4-isocyanatobenzoate (52.3 mmol, 10 g) in dichloromethane (45 mL) and the reaction stirred overnight. The reaction was then concentrated under reduced pressure to give the title compound (14.7 g).

後処理

  1. concentrationThe reaction was then concentrated under reduced pressure

出典と根拠

ORDレコード
ord-a025eb4f1c524d379e0511ca45ef8992
出典データセット
uspto-grants-2014_06
特許番号
US08759352B2

反応ノート

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