Dichloromethane → HCID 86662562、化合物

HRID 408969

反応式

HRID 408969 の反応式
S([C:5]1[CH:11]=[CH:10][C:8]([CH3:9])=[CH:7][CH:6]=1)([O-])(=O)=O.C(O[NH:20][C@H:21]([C:23]([OH:25])=[O:24])[CH3:22])C1C=CC=CC=1.[P:26](Cl)(Cl)(=[O:38])[O:27][C:28]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:31]=[CH:30][CH:29]=1.C(Cl)[Cl:42]>>[Cl:42][C:29]1[CH:30]=[CH:31][C:32]2[C:37](=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:28]=1[O:27][P:26](=[N:20][C@@H:21]([CH3:22])[C:23]([O:25][CH2:9][C:8]1[CH:10]=[CH:11][CH:5]=[CH:6][CH:7]=1)=[O:24])=[O:38]

参加物

5

反応物 4

HCID 6344DichloromethaneHCID 85570p-ToluenesulfonateHCID 5756311-DichlorophosphoryloxynaphthaleneHCID 13028072benzyloxy-L-alanine

生成物 1

HCID 86662562HCID 86662562、化合物収率 89%

実験手順

Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates the tosylate salt of benzyloxy-L-alanine (1.5 g), naphthalen-1-yl phosphorodichloridate (1.10 g), TEA (1.14 mL), and DCM (20 mL) were combined to give (2S)-benzyl 2-(chloro(naphthalen-1-yloxy)-phosphorylamino)-propanoate in an 89% yield (1.53 g), as a pale yellow thick oil.

出典と根拠

ORDレコード
ord-df86005e653c4a39b160ebaba0a455e7
出典データセット
uspto-grants-2014_06
特許番号
US08759318B2

関連ノート

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