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Dichloromethane → (2S)-isobutyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | p-Toluenesulfonate | HCID 85570 | — |
| 反応物 | 1-Dichlorophosphoryloxynaphthalene | HCID 575631 | — |
| 反応物 | 2-methylpropyl (2S)-2-aminopropanoate | HCID 13743556 | — |
| 生成物 | (2S)-isobutyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)propanoate | HCID 66778743 | — |
反応手順
Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates, the tosylate salt of (S)-isobutyl 2-aminopropanoate (2.5 g), naphthalen-1-yl phosphorodichloridate (2.06 g), TEA (2.19 mL) and DCM (50 mL) were combined to give (2S)-isobutyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)propanoate as a crude pale yellow thick oil. The crude compound was taken forward without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08759318B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-01f4de3f1ec5446fa281653c52750d37 |
| 出典メモ | uspto-grants-2014_06 |