化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → (2S)-methyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-2-phenylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1-Dichlorophosphoryloxynaphthalene | HCID 575631 | — |
| 反応物 | Methyl phenylglycinate, L- | HCID 1201451 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (2S)-methyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-2-phenylacetate | HCID 66779381 | — |
反応手順
Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates, the HCl salt of (S)-methyl 2-amino-2-phenylacetate (2 g), naphthalen-1-yl phosphorodichloridate (2.59 g), TEA (2.76 mL) and DCM (60 mL) were combined to give (2S)-methyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-2-phenylacetate as a pale yellow thick oil. The crude compound was taken forward without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08759318B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-1263948a19004717ad6165216af6756f |
| 出典メモ | uspto-grants-2014_06 |