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Triacetoxyperiodinane → (1-Formylcyclopropyl)carbamic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triacetoxyperiodinane | HCID 159087 | — |
| 反応物 | tert-butyl N-(1-(hydroxymethyl)cyclopropyl)carbamate | HCID 11286907 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (1-Formylcyclopropyl)carbamic acid tert-butyl ester | HCID 10352385 | 87% |
反応手順
To a solution of tert-butyl (1-(hydroxymethyl)cyclopropyl)carbamate (Bioorg. Med. Chem. Lett., 2008, 18(6), 2188) (135 mg, 0.72 mmoles) in DCM (8 mL) was added Dess-Martin periodinane (277 mg, 0.65 mmole). After stirring 1 hr, the reaction was filtered through celite and concentrated to a yellow oil which was further purified by Isolera (7%-70% ethyl acetate/hexanes) to provide 84 mg (87%) of tert-butyl (1-formylcyclopropyl)-carbamate as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08759358B1 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-6a8cbcfd92364f9db8d0711fef89a97d |
| 出典メモ | uspto-grants-2014_06 |