関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 2,2-Dimethyl-4-butyrolactone | HCID 94746 | — |
| 触媒 | Phenolphthalein | HCID 4764 | — |
| 溶媒 | Water ethanol | HCID 19096565 | — |
| 生成物 | Potassium 4-hydroxy-2,2-dimethylbutyrate | HCID 23712640 | 71.1% |
反応手順
A mixture of dihydro-3,3-dimethyl-2(3H)-furanone (10 mmol; 1.14 g), aqueous 1 M KOH solution (10 mmol) and one drop of phenolphthalein indicator (0.5% w/v in EtOH/water (1:1)) is stirred at 105° C. for 3.5 hours. The mixture is cooled to ambient temperature and concentration under reduced pressure. To the residue is added 10 mL of EtOH. To the solution is added 50 ml of Et2O, and the solid isolated by filtration and dried under 100 mbar at 50° C. to give potassium 4-hydroxy-2,2-dimethylbutyrate (1.21 g, 71%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08759365B2 |
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| 出典データセット | uspto-grants-2014_06 |
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| ORD ID | ord-35ae9b314b1645268a359b196c797298 |
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| 出典メモ | uspto-grants-2014_06 |
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