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Dimethylamine → HCID 22899422、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylamine | HCID 674 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2,4-Dichloropyrimidine-5-carbonyl chloride | HCID 13784112 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 22899422 | HCID 22899422 | 158.8% |
反応手順
To a solution of 2,4-dichloro-pyrimidine-5-carbonyl chloride (197.7 mg, 0.94 mmol) in CH2Cl2 (9.4 mL) at RT is added Me2NH (2.0 M THF solution, 390 μL, 0.78 mmol) and Et3N (108.6 μL, 0.78 mmol) at 0° C. The reaction mixture is stirred overnight at RT. After adding water, the mixture is extracted with CH2Cl2. The organic layer is dried and concentration under reduce pressure give 2,4-dichloro-pyrimidine-5-carboxylic acid dimethylamide (272.5 mg, quant). ESI-MS m/z: 221 [M+1]+, Retention time 1.94 min (condition B).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08759365B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-856aba5aff5341e091ab4f4ba329994d |
| 出典メモ | uspto-grants-2014_06 |