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1-Ethyl-4-(4-nitrophenyl)piperazine → 4-(4-Ethylpiperazin-1-yl)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Ethyl-4-(4-nitrophenyl)piperazine | HCID 2857549 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-(4-Ethylpiperazin-1-yl)aniline | HCID 936738 | — |
反応手順
A suspension of 1-ethyl-4-(4-nitro-phenyl)-piperazine (6.2 g, 26.35 mmol) and Raney Nickel (2 g) in MeOH (120 mL) is stirred for 7 h at RT, under a hydrogen atmosphere. The reaction mixture is filtered through a pad of celite and concentrated to afford the title compound as a violet solid: ESI-MS: 206.1 [MH]+; TLC: Rf=0.15 (DCM/MeOH+1% NH3aq, 9:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08759517B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-ee549fa061d64d3abbf0f8aeec8dc3b8 |
| 出典メモ | uspto-grants-2014_06 |