4-Bromophenol → 1-Bromo-4-(cyclobutyloxy)benzene
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH:9]1(Br)[CH2:12][CH2:11][CH2:10]1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH:9]2[CH2:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1参加物
6
反応条件
- 温度
- 120 °C
実験手順
2.50 g (14.5 mmol) 4-bromophenol, 2.05 mL (21.7 mmol) cyclobutylbromide and 7.99 g (57.8 mmol) K2CO3 are dissolved in 25 mL DMF and stirred at 120° C. for 12 h. Afterwards the reaction mixture is diluted with water and extracted with EtOAc. The organic layer is dried over MgSO4 and the solvent is removed in vacuo. The crude product is used without further purification.
後処理
- extractionextracted with EtOAc
- dry with materialThe organic layer is dried over MgSO4
- customthe solvent is removed in vacuo
- customThe crude product is used without further purification
出典と根拠
- ORDレコード
- ord-86f47b0fec1549db966c451350fe63cd
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08759528B2
反応ノート
読み込み中…