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Hydrazine → Isoquinoline-3-carbohydrazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazine | HCID 9321 | — |
| 反応物 | Methyl 3-isoquinolinecarboxylate | HCID 725374 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Isoquinoline-3-carbohydrazide | HCID 55263898 | 86% |
反応手順
To a solution of methyl isoquinoline-3-carboxylate (10 g, 53.42 mmol) in ethanol (100 mL) was added hydrazine (17.1 g). The reaction mixture was refluxed for 30 min and concentrated under high vacuum to remove hydrazine. The resulting residue was triturated with ethanol (20 mL) to give isoquinoline-3-carbohydrazide (8.6 g, 86%). LRMS (M+H+) m/z 188.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08759374B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-4011f0480f4e446aa3625771427965f9 |
| 出典メモ | uspto-grants-2014_06 |