Sodium Acetate → 3-(2,4-Dimethyl-phenyl)-5-[5-(3-nitro-phenyl)-furan-2-ylmethylene]-2-thioxo-thiazolidin-4-one

関与物質

反応手順

In 4.7 mL of 0.2 M ethanol was dissolved 0.1 g of 3-(2,4-dimethyl-phenyl)-2-thioxo-thiazolidin-4-one (0.42 mmol) synthesized in 1. The solution was mixed with 0.11 g of sodium acetate (1.34 mmol) and 0.15 g of 5-(3-nitro-phenyl)-furan-2-carboaldehyde (0.69 mmol), synthesized in 2, with stirring, and then heated for 4 hrs. The resulting reaction mixture was washed with ethanol to afford the title compound as a solid. When a solid was not formed, purification by silica gel column chromatography afforded 0.54 g of the title compound (yield: 28.6%).

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