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HRID 409946作成日：2026年10月25日

3,5-Bis(difluoromethyl)-1H-pyrazole-1-acetic acid → 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}-benzaldehyde

https://huagongshe.com/reaction/409946

反応式

関与物質

役割名称HCID仕込み量
反応物3,5-Bis(difluoromethyl)-1H-pyrazole-1-acetic acidHCID 1229844—
反応物HCID 178519461HCID 178519461—
生成物2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}-benzaldehydeHCID 86657566—

反応手順

4-{4-[5-(2-Formylphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidinium chloride (433 mg) and [3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid (285 mg) were reacted analogously to I-40 (step 3). This gave 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-O-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}benzaldehyde (330 mg).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08759527B2
出典データセットuspto-grants-2014_06
ORD IDord-6d927205360743d0a103329fc7a23125
出典メモuspto-grants-2014_06