関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 1,3-Dichloro-2-nitrobenzene | HCID 11759 | — |
| 反応物 | 2,2,2-Trifluoro-N-(hydroxymethyl)acetamide | HCID 3084931 | — |
| 生成物 | HCID 56839981 | HCID 56839981 | — |
反応手順
N-(Hydroxymethyl)trifluoroacetamide (6.6 mmol; 0.946 g) is added to a mixture of 2,6-dichloro-nitrobenzene (0.899 mL; 6.6 mmol) and conc. H2SO4 (15 mL) at 75° C. The mixture is stirred at 75° C. overnight, poured into ice water and stirred for 1 h. The precipitate is collected by filtration and dried. Yield 0.32 g (15%). MS [M−H]−=315, HPLC-method B: Rt=1.43 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08759537B2 |
|---|
| 出典データセット | uspto-grants-2014_06 |
|---|
| ORD ID | ord-553a012956504cd28fabbf1743ebf0b1 |
|---|
| 出典メモ | uspto-grants-2014_06 |
|---|
