Diisopropylcarbodiimide → HCID 178425577、化合物

反応式

[F:1][C:2]([F:27])([F:26])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:25])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH:18][CH3:19])=[CH:13][C:12]=2[O:20][CH2:21][CH:22]([F:24])[F:23])[CH2:5][CH2:4]1.[CH3:28][C:29]1[C:42]([N:43]=[C:44]=S)=[C:41]([CH3:46])[CH:40]=[CH:39][C:30]=1[CH2:31][NH:32][C:33](=[O:38])[C:34]([CH3:37])([CH3:36])[CH3:35].CC(C)N=C=NC(C)C>>[F:1][C:2]([F:26])([F:27])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10]([C:11]2[C:12]([O:20][CH2:21][CH:22]([F:23])[F:24])=[CH:13][C:14]3[N:18]([CH3:19])[C:44]([NH:43][C:42]4[C:41]([CH3:46])=[CH:40][CH:39]=[C:30]([CH2:31][NH:32][C:33](=[O:38])[C:34]([CH3:37])([CH3:36])[CH3:35])[C:29]=4[CH3:28])=[N:17][C:15]=3[CH:16]=2)=[O:25])[CH2:5][CH2:4]1

参加物

反応物 3

HCID 12734Diisopropylcarbodiimide

HCID 56840195N-(2,4-Dimethyl-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide

HCID 178482270HCID 178482270、化合物

生成物 1

HCID 178425577HCID 178425577、化合物

実験手順

The title compound is prepared from N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzoic acid amide and N-(2,4-dimethyl-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide with DIC in analogy to examples 7b/7c.

出典と根拠

ORDレコード: ord-f9498e1f36804d9eae59246354e0570d
出典データセット: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08759537B2

反応ノート

読み込み中…