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Diisopropylamine → N-[1-cyano-1-methyl-2-(5-cyano-2-{2-chloro-4-trifluoromethoxy-phenoxy}-phenoxy)-ethyl]-4-trifluoromethylsulfanyl-benzamide

HRID 410124
ノート
印刷プレビュー

反応式

HRID 410124 の反応式
[NH2:1][C:2]([C:27]#[N:28])([CH3:26])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][C:12]=1[O:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][C:15]=1[Cl:25])[C:8]#[N:9].C(NC(C)C)(C)C.[F:36][C:37]([F:49])([F:48])[S:38][C:39]1[CH:47]=[CH:46][C:42]([C:43](Cl)=[O:44])=[CH:41][CH:40]=1>ClCCl>[C:27]([C:2]([NH:1][C:43](=[O:44])[C:42]1[CH:46]=[CH:47][C:39]([S:38][C:37]([F:49])([F:36])[F:48])=[CH:40][CH:41]=1)([CH3:26])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:8]#[N:9])[CH:10]=[CH:11][C:12]=1[O:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]([F:23])([F:24])[F:22])=[CH:16][C:15]=1[Cl:25])#[N:28]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 7912DiisopropylamineHCID 27778654-(Trifluoromethylthio)benzoyl chlorideHCID 673925753-(2-Amino-2-cyano-2-methyl-ethoxy)-4-(2-chloro-4-trifluoromethoxy-phenoxy)-benzonitrile

生成物 1

HCID 53238880N-[1-cyano-1-methyl-2-(5-cyano-2-{2-chloro-4-trifluoromethoxy-phenoxy}-phenoxy)-ethyl]-4-trifluoromethylsulfanyl-benzamide

試薬・触媒・溶媒 1

HCID 6344
Dichloromethane
溶媒

実験手順

21.5 g of 3-(2-amino-2-cyano-2-methyl-ethoxy)-4-(2-chloro-4-trifluoromethoxy-phenoxy)-benzonitrile (described in example 1 step d)) and 11.4 ml of N, N-diisopropylamine are dissolved in 250 ml of dichloromethane and 14.5 g of 4-(trifluoromethylthio)-benzoylchloride are slowly added. The reaction mixture is stirred at room temperature for 20 hours and washed with water, a saturated aqueous solution of sodium bicarbonate and water. The organic phase is dried with magnesium sulfate and evaporated under vacuum. The residue is purified by recrystallization from diethylether/hexanes to yield N-[1-cyano-1-methyl-2-(5-cyano-2-{2-chloro-4-trifluoromethoxy-phenoxy}-phenoxy)-ethyl]-4-trifluoromethylsulfanyl-benzamide as a colorless solid.

後処理

  1. washwashed with water
  2. dry with materialThe organic phase is dried with magnesium sulfate
  3. customevaporated under vacuum
  4. customThe residue is purified by recrystallization from diethylether/hexanes

出典と根拠

ORDレコード
ord-b877c419057440a694e2d4c594fc5970
出典データセット
uspto-grants-2014_06
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08759564B2

反応ノート

読み込み中…

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