関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 3-Bromo-5-methylaniline | HCID 3018526 | — |
| 反応物 | 2-Chloro-4-isopropylpyrimidine | HCID 24901916 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | N-(3-bromo-5-methylphenyl)-4-(propan-2-yl)-pyrimidin-2-amine | HCID 67248097 | 98.1% |
反応手順
Acetic acid (0.192 mL, 3.35 mmol) was added to commercially available 2-chloro-4-(propan-2-yl)pyrimidine (0.5 g, 3.19 mmol) and 3-bromo-5-methylaniline (0.900 g, 3.19 mmol) suspended in dioxane (6.39 mL). Reaction was heated to 120° C. (bath temp) overnight. Then, the reaction was cooled to room temperature and purified by column chromatography on silica gel eluting with ethyl acetate and hexanes to give N-(3-bromo-5-methylphenyl)-4-(propan-2-yl)-pyrimidin-2-amine (959.8 mg, 3.13 mmol, 98%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08759366B2 |
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| 出典データセット | uspto-grants-2014_06 |
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| ORD ID | ord-6f0a6f8c243e448aacaf35fdaef543d9 |
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| 出典メモ | uspto-grants-2014_06 |
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