6-Fluoroindole → Sodium 6-Fluoro-1H-indole-2-sulfonate

HRID 41066

反応式

HRID 41066 の反応式
[S:1](=[O:4])([OH:3])[O-:2].[Na+:5].[F:6][C:7]1[CH:15]=[C:14]2[C:10]([CH:11]=[CH:12][NH:13]2)=[CH:9][CH:8]=1>O.C(O)C>[F:6][C:7]1[CH:15]=[C:14]2[C:10]([CH:11]=[C:12]([S:1]([O-:3])(=[O:2])=[O:4])[NH:13]2)=[CH:9][CH:8]=1.[Na+:5]

参加物

5

反応物 2

HCID 3512786-FluoroindoleHCID 23665763Sodium Bisulfite

生成物 1

HCID 86634332Sodium 6-Fluoro-1H-indole-2-sulfonate収率 29.5%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a solution of 23.4 g sodium bisulfite in 80 ml water a solution of 13.5 g 6-fluoro indole in ethanol is added drop wise. The obtained suspension is stirred at room temperature over night. The precipitate is filtered and washed with cold water, cold methanol and diethyl ether. 7.0 g (29%) of the title compound are obtained as a colourless solid.

後処理

  1. filtrationThe precipitate is filtered
  2. washwashed with cold water, cold methanol and diethyl ether

出典と根拠

ORDレコード
ord-524347121123467c90bcf38b3fc5d8c2
出典データセット
uspto-grants-2013_09
特許番号
US08530493B2

関連ノート

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