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HRID 410725作成日：2026年10月27日

Ethylamine → 1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid ethylamide

https://huagongshe.com/reaction/410725

反応式

関与物質

役割名称HCID仕込み量
反応物EthylamineHCID 6341—
反応物DiisopropylethylamineHCID 81531—
反応物P,P-Diphenylphosphinic azideHCID 199401—
反応物1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acidHCID 58397517—
生成物1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid ethylamideHCID 86656749—

反応手順

1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid ethylamide (17 mg) was prepared by following General Procedure N starting from 1-methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid (100 mg), ethylamine (2 M in THF, 123 uL), DPPA (53 uL), and DIEA (43 uL). LC/MS: 436.9 m/z (M+1)+. 1H NMR (DMSO-d6, 400 MHz): δ 8.43 (s, 1H), 8.07 (s, 1H), 7.89 (s, 1H), 7.79-7.65 (m, 2H), 7.46 (d, 1H), 7.35 (s, 1H), 3.62 (bs, 3H), 3.30-3.23 (m, 2H), 1.13 (t, 3H), —NH proton signal was not observed.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08759535B2
出典データセットuspto-grants-2014_06
ORD IDord-b13a511b02124e779e6bcd10a1fcce30
出典メモuspto-grants-2014_06