1,2-Dichloroethane → 1-Ethyl-2-(6-trifluoromethyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid methyl ester

HRID 410928

反応式

HRID 410928 の反応式
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH3:12])=[C:6]([NH2:13])[CH:5]=1.[F:15][C:16]([F:28])([F:27])[C:17]1[CH:26]=[CH:25][C:20]2[N:21]=[C:22]([NH2:24])[S:23][C:19]=2[CH:18]=1.[C:29](N1C=CN=C1)(N1C=CN=C1)=S.C(Cl)CCl>CN(C=O)C>[CH3:1][O:2][C:3]([C:4]1[CH:9]=[CH:8][C:7]2[N:10]([CH2:11][CH3:12])[C:29]([NH:24][C:22]3[S:23][C:19]4[CH:18]=[C:17]([C:16]([F:15])([F:27])[F:28])[CH:26]=[CH:25][C:20]=4[N:21]=3)=[N:13][C:6]=2[CH:5]=1)=[O:14]

参加物

6

反応物 4

HCID 111,2-DichloroethaneHCID 802641,1'-ThiocarbonyldiimidazoleHCID 27359552-Amino-6-(trifluoromethyl)benzothiazoleHCID 12758354Methyl 3-amino-4-(ethylamino)benzoate

生成物 1

HCID 866568641-Ethyl-2-(6-trifluoromethyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid methyl ester収率 43.6%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

1-Ethyl-2-(6-trifluoromethyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid methyl ester (840.0 mg) was prepared by following General Procedure D starting from 3-amino-4-ethylamino-benzoic acid methyl ester (970.0 mg), 6-trifluoromethyl-benzothiazol-2-ylamine (1.0 g), 1,1′-thiocarbonyldiimidazole (890.0 mg), and EDC (970.0 mg) in DMF (5.0 mL).

出典と根拠

ORDレコード
ord-1e502cf105c44a79ac98d461515d1133
出典データセット
uspto-grants-2014_06
特許番号
US08759535B2

関連ノート

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