Hydrochloric Acid → 3,5-Difluoro-4-formylbenzoic acid

温度

-78 °C

To a solution of 3,5-difluorobenzoic acid (291 g, 1.84 mol) in 2-methyltetrahydrofuran (4.35 L) was added TMEDA (604 mL, 4.03 mol) at room temperature. The resulting solution was cooled to −78° C. Afterward, n-BuLi (2.5 M in hexane) (1.77 L, 4.43 mol) was added drop-wise, during which the temperature of the mixture remained at less than −65° C. The mixture was then stirred at −78° C. for 1.5 hr. Anhydrous MeOCHO (239 mL, 3.88 mol) was added dropwise at a rate that allowed the temperature to be maintained at less than −65° C. The resulting solution was allowed to warm at room temperature, and then maintained a room temperature while being stirred for 18 hr. The mixture was then cooled to 0-5° C., and excess base was quenched with 6M aqueous HCl (2.2 L, 13.2 mol). The phases were then separated, and the aqueous layer was extracted 3 times with 2-methyltetrahydrofuran (3×500 mL). The combined organic phases were washed with saturated brine, dried over MgSO4, filtered, and concentrated under vacuum. The residue was dissolved in ethyl acetate (350 mL) at reflux, and cooled to room temperature. Hexanes (480 mL) were then added, and the resulting mixture was further cooled to −15° C. The solid was collected by filtration, rinsed with hexanes, and dried under mechanical vacuum to form the title compound (122 g, 35%) as a solid. 1H NMR (300 MHz, DMSO-d6) δ ppm 7.63-7.70 (m, 2H), 10.23 (s, 1H); MS m/z 187.17 [M+H]+ (ESI).

1. customremained at less than −65° C
2. temperatureto be maintained at less than −65° C
3. temperatureto warm at room temperature
4. temperaturemaintained a room temperature
5. stirringwhile being stirred for 18 hr
6. temperatureThe mixture was then cooled to 0-5° C.
7. customThe phases were then separated
8. extractionthe aqueous layer was extracted 3 times with 2-methyltetrahydrofuran (3×500 mL)
9. washThe combined organic phases were washed with saturated brine
10. dry with materialdried over MgSO4
11. filtrationfiltered
12. concentrationconcentrated under vacuum
13. dissolutionThe residue was dissolved in ethyl acetate (350 mL)
14. temperatureat reflux
15. temperaturecooled to room temperature
16. additionHexanes (480 mL) were then added
17. temperaturethe resulting mixture was further cooled to −15° C
18. filtrationThe solid was collected by filtration
19. washrinsed with hexanes
20. customdried under mechanical vacuum

ORDレコード

ord-3c3d179a029841c99c677f03951c30f8

出典データセット

uspto-grants-2013_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08530467B2