N-(2-Chloroethyl)dibenzylamine → HCID 67332450、化合物

HRID 410988

反応式

HRID 410988 の反応式
[CH2:1]([N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:9][CH2:10]Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19]([O:23][C:24](=[O:30])[N:25]([CH2:27][CH2:28][OH:29])[CH3:26])([CH3:22])([CH3:21])[CH3:20].[OH-].[K+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.O1CCOCC1>[C:19]([O:23][C:24](=[O:30])[N:25]([CH2:27][CH2:28][O:29][CH2:10][CH2:9][N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH3:26])([CH3:22])([CH3:20])[CH3:21]

参加物

6

反応物 3

HCID 5820N-(2-Chloroethyl)dibenzylamineHCID 14797Potassium HydroxideHCID 545700N-(tert-Butoxycarbonyl)-N-methyl-2-aminoethanol

生成物 1

HCID 67332450HCID 67332450、化合物収率 32.6%

試薬・触媒・溶媒 2

HCID 74236Tetrabutylammonium Bromide触媒HCID 312751,4-Dioxane溶媒

実験手順

[2-(2-Dibenzylamino-ethoxy)-ethyl]-methyl-carbamic acid tert-butyl ester (200 mg) was prepared by following General Procedure S starting from dibenzyl-(2-chloro-ethyl)-amine (400 mg), (2-hydroxy-ethyl)-methyl-carbamic acid tert-butyl ester (525 mg), 50% (w/w) KOH solution (1.8 mL) and tetrabutylammonium bromide (57.7 mg) in dioxane (1.8 mL).

出典と根拠

ORDレコード
ord-843280e7221d4553b5e61ad4043f6770
出典データセット
uspto-grants-2014_06
特許番号
US08759535B2

関連ノート

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