(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → 4-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-4-phenyl-1,2,3,4-tetrahydroisoquinolin-3-one

HRID 411343ノート

反応式

HRID 411343 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([OH:17])=O)[CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[NH2:18][CH:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22](C2C=NC=CC=2)[NH:21][C:20]1=[O:35]>>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([NH:18][C:19]2([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:22][NH:21][C:20]2=[O:35])=[O:17])[CH3:14])=[O:11])[CH:3]=[C:2]([F:1])[CH:7]=1

参加物

3

反応物 2

HCID 12135350(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acidHCID 223127724-Amino-1-(pyrid-3-yl)-1,2,3,4-tetrahydroisoquinoline-3-one

生成物 1

HCID 205829494-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-4-phenyl-1,2,3,4-tetrahydroisoquinolin-3-one

実験手順

Following General Procedure D above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 4-amino-6-phenyl-1,2,3,4-tetrahydroisoquinoline-3-one (General Procedure 5-D), the title compound was prepared. The product was purified by LC 2000 chromatography, eluting with ethyl acetate.

後処理

  1. customThe product was purified by LC 2000 chromatography
  2. washeluting with ethyl acetate

出典と根拠

ORDレコード
ord-fc6d75b237034f57908c9732cf631003
出典データセット
uspto-grants-2003_05
特許番号
US06559141B2

反応ノート

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