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Pyridine → Isobutyl 2-bromopropionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Isobutanol | HCID 6560 | — |
| 反応物 | Propanoyl bromide, 2-bromo- | HCID 79047 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Isobutyl 2-bromopropionate | HCID 522337 | — |
反応手順
To a mixture of iso-butanol and 1.0 equivalent of pyridine in dry diethyl ether was added dropwise 1.3 equivalents of 2-bromopropionyl bromide at 0° C. After stirring at room temperature for 16 hours, the reaction was diluted with diethyl ether, washed with 1N HCl, water, aqueous NaHCO3, brine and dried over magnesium sulfate or sodium sulfate. Removal of the solvents at reduced pressure gave the title compound as a clear oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06559141B2 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-20cbe2b67e65447792196bd6937e9bc0 |
| 出典メモ | uspto-grants-2003_05 |