Fluorophenylacetic acid → 4-(4-Bromophenylsulphonyl)-1-(2-fluoro-2-phenylethyl)piperidine

関与物質

反応手順

4-(4-Bromophenylsulphonyl)piperidine (0.7 g, 2.3 mmol) was reacted with α-fluorophenylacetic acid (0.53 g, 3.45 mmol) in a similar manner as described for Example 13, Steps a and b, to give the required product as a colourless solid, 0.56 g (58%), m.p. 126-127° C. (EtOAc-pet. ether 60-80°). δH (400 MHz, CDCl3) 1.70-1.77 (2H, m), 2.00-2.03 (2H, m), 2.13-2.20 (2H, m), 2.57-2.69 (1H, m), 2.83-2.93 (2H, s), 3.04-3.18 (2H, m), 5.51-5.65 (1H, m), 7.28-7.39 (5H, m), 7.70-7.75 (4H, m).

情報源と証拠