Ammonium Hydroxide → 4-{[(2R)-3-Amino-2-hydroxypropyl]oxy}benzonitrile

HRID 411540ノート

反応式

HRID 411540 の反応式
[O:1]1[CH2:3][C@@H:2]1[CH2:4][O:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1.[NH4+:14].[OH-]>C(O)(C)C>[NH2:14][CH2:3][C@@H:2]([OH:1])[CH2:4][O:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 6934186(R)-4-(Oxiran-2-ylmethoxy)benzonitrile

生成物 1

HCID 300720964-{[(2R)-3-Amino-2-hydroxypropyl]oxy}benzonitrile収率 91%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

4-[(2R)-Oxiranylmethoxy]benzonitrile (see step (i) above; 14.65 g, 83.6 mmol) was mixed with NH4OH (conc., 64 mL) and 87 mL of isopropanol. The mixture was stirred at rt for 18 h. The reaction mixture was then filtered and evaporated to give 14.6 g (91%) of the sub-title compound as a white solid.

後処理

  1. filtrationThe reaction mixture was then filtered
  2. customevaporated

出典と根拠

ORDレコード
ord-dab5659829564b2dac29ccc1ae92c8e7
出典データセット
uspto-grants-2003_05
特許番号
US06559162B2

反応ノート

読み込み中…