Hydrochloric Acid → 2,2,2-Trifluoro-1-[8-(methylamino)-3-azabicyclo[3.2.1]oct-3-yl]-1-ethanone
反応式
Cl.[CH3:2][N:3]([CH:11]1[CH:16]2[CH2:17][CH2:18][CH:12]1[CH2:13][N:14]([C:19](=[O:24])[C:20]([F:23])([F:22])[F:21])[CH2:15]2)C(=O)OC(C)(C)C>C(OCC)(=O)C>[F:23][C:20]([F:21])([F:22])[C:19]([N:14]1[CH2:15][CH:16]2[CH:11]([NH:3][CH3:2])[CH:12]([CH2:18][CH2:17]2)[CH2:13]1)=[O:24]参加物
4
実験手順
Ethyl acetate (100 mL) saturated with HCl (g) was added, at 0° C., to a solution of tert-butyl methyl[3-(2,2,2-trifluoroacetyl)-3-azabicyclo[3.2.1]oct-8-yl]carbamate (see step (iv) above; 5 g, 15 mmol) in ethyl acetate (50 mL). The mixture was allowed to reach rt over the course of 3 h, after which time the solvent was evaporated. This gave 4 g (100%) of the sub-tide compound hydrochloride salt.
後処理
- customto reach rt over the course of 3 h
- customafter which time the solvent was evaporated
出典と根拠
- ORDレコード
- ord-3af994ae65634fc6a9bc67365171e809
- 出典データセット
- uspto-grants-2003_05
- 特許番号
- US06559162B2
反応ノート
読み込み中…