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1-(2-Hydroxyethyl)piperazine → 1-Acetyl-4-(2-hydroxyethyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Acetyl-4-(2-hydroxyethyl)piperazine | HCID 4739629 | 65% |
反応手順
A solution of 2-(1-piperazinyl)-1-ethanol (6.5 g, 0.05 mol) in DCM (5 mL) was treated with acetic acid anhydride (5.1 g, 0.05 mol), added dropwise. During addition, the reaction temperature rose from 22 to 60° C. The reaction mixture was evaporated several times with toluene to yield 5.6 g (65%) of the sub-title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06559162B2 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-719de8e84b1941b0afa086c4c952fcc5 |
| 出典メモ | uspto-grants-2003_05 |