1-(2-Hydroxyethyl)piperazine → 1-Acetyl-4-(2-hydroxyethyl)piperazine

HRID 411554

反応式

HRID 411554 の反応式
[N:1]1([CH2:7][CH2:8][OH:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>C(Cl)Cl>[OH:9][CH2:8][CH2:7][N:1]1[CH2:6][CH2:5][N:4]([C:10](=[O:12])[CH3:11])[CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 7918Acetic Anhydride

生成物 1

HCID 47396291-Acetyl-4-(2-hydroxyethyl)piperazine収率 65%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 2-(1-piperazinyl)-1-ethanol (6.5 g, 0.05 mol) in DCM (5 mL) was treated with acetic acid anhydride (5.1 g, 0.05 mol), added dropwise. During addition, the reaction temperature rose from 22 to 60° C. The reaction mixture was evaporated several times with toluene to yield 5.6 g (65%) of the sub-title compound.

後処理

  1. additionadded dropwise
  2. additionDuring addition
  3. customrose from 22 to 60° C
  4. customThe reaction mixture was evaporated several times with toluene

出典と根拠

ORDレコード
ord-719de8e84b1941b0afa086c4c952fcc5
出典データセット
uspto-grants-2003_05
特許番号
US06559162B2

関連ノート

読み込み中…