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Sodium Cyanide → (4R *,5R*)-5-(4-chloro-3-trifluoromethyl-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | 4-Chloro-3-(trifluoromethyl)benzaldehyde | HCID 118642 | — |
| 反応物 | Tosylmethyl isocyanide | HCID 161915 | — |
| 生成物 | (4R *,5R*)-5-(4-chloro-3-trifluoromethyl-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole | HCID 69556945 | — |
反応手順
In a manner analogous to Preparation 1, 4-chloro-3-(trifluoromethyl)benzaldehyde (0.31 g, 1.47 mmol), tosylmethylisocyanide (0.27 g, 1.40 mmol) and NaCN (6.9 mg, 0.14 mmol) gave the desired compound as a tan solid. MS(ES+) m/z 404.5 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06559172B1 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-2062fb24d3e14162a441c15b1be6598e |
| 出典メモ | uspto-grants-2003_05 |