化工社化工社 化学情報印刷レポート · 研究参考用
4-Bromo-3-phenyl-1H-pyrazol-5-amine → 3-[[(4-bromo-5-phenyl-1H-pyrazol-3-yl)amino]methylidene]-4-methyl-1H-indol-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromo-3-phenyl-1H-pyrazol-5-amine | HCID 594319 | — |
| 反応物 | HCID 178418806 | HCID 178418806 | — |
| 反応物 | HCID 178423596 | HCID 178423596 | — |
| 反応物 | HCID 178517101 | HCID 178517101 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-[[(4-bromo-5-phenyl-1H-pyrazol-3-yl)amino]methylidene]-4-methyl-1H-indol-2-one | HCID 178423595 | — |
反応手順
The named compound is prepared by substituting E & Z-3-[(hydroxy)-methylene]-4-methyl-1,3-dihydro-indol-2-one for E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one and 4-bromo-5-phenyl-1H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-4-methyl-1,3-dihydro-indol-2-one (0.1622 gms.) is reacted with 0.4530 gms. of 4-bromo-5-phenyl-1H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (3.0 mL).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06559173B1 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-60f37002e36a4a62a973846351568cc2 |
| 出典メモ | uspto-grants-2003_05 |