関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Decanoic Acid | HCID 2969 | — |
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Chloromethyl chlorosulfate | HCID 2733556 | — |
| 触媒 | Tetrabutylammonium hydrogen sulfate | HCID 94433 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Chloromethyl decanoate | HCID 572571 | 100% |
反応手順
Decanoic acid (0.2 gm, 1.2 mmol) was treated with 4 eq NaHCO3, 0.1 eq Bu4NHSO4 and, 1.2 eq ClCH2OSO2Cl in 1:1 CH2Cl2:H2O. The reaction was stirred vigorously at 0° C. for 30 min then room temperature (“RT”) for 3 hrs. Aqueous workup yielded chloromethyldecanoate (yield 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06559164B1 |
|---|
| 出典データセット | uspto-grants-2003_05 |
|---|
| ORD ID | ord-01ffc514e7334937b06f28c9c7eef12f |
|---|
| 出典メモ | uspto-grants-2003_05 |
|---|
