Sodium Bicarbonate → HCID 9851675、化合物

HRID 411773ノート

反応式

HRID 411773 の反応式
F[C:2](F)(F)[C:3]([OH:5])=[O:4].[CH3:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([C:18]2[C:19](=[O:47])[N:20]([CH2:37][O:38][C:39]([CH:41]3[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]3)=[O:40])[C:21](=[O:36])[C:22]=2[C:23]2[C:31]3[C:26](=[CH:27][C:28]([N+:32]([O-:34])=[O:33])=[CH:29][CH:30]=3)[N:25]([CH3:35])[CH:24]=2)=[CH:10]1.C([O-])(O)=O.[Na+]>C(OCC)(=O)C>[C:3]([OH:5])(=[O:4])[CH3:2].[CH3:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([C:18]2[C:19](=[O:47])[N:20]([CH2:37][O:38][C:39]([CH:41]3[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]3)=[O:40])[C:21](=[O:36])[C:22]=2[C:23]2[C:31]3[C:26](=[CH:27][C:28]([N+:32]([O-:34])=[O:33])=[CH:29][CH:30]=3)[N:25]([CH3:35])[CH:24]=2)=[CH:10]1

参加物

4

反応物 2

HCID 516892Sodium BicarbonateHCID 69945384HCID 69945384、化合物

生成物 1

HCID 9851675HCID 9851675、化合物収率 97%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Piperidine-4-carboxylic acid 3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-pyrrol-1-ylmethyl ester trifluoroacetate, prepared as in example 8a above, was dissolved in ethyl acetate. The resulting solution was neutralized with cold saturated NaHCO3. The ethyl acetate layer was concentrated and slurried in H2O and acidified with excess HOAc and lyophilized to give the desired product (yield—97%).

後処理

  1. concentrationThe ethyl acetate layer was concentrated and slurried in H2O

出典と根拠

ORDレコード
ord-b0edc6bffe5648f4be3317a0bdda8d7b
出典データセット
uspto-grants-2003_05
特許番号
US06559164B1

反応ノート

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