Sulfuric Acid → 5-Chlorohexanoic acid

HRID 411804

反応式

HRID 411804 の反応式
[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[Cl:9]N(C(C)C)C(C)C.S(=O)(=O)(O)O>>[Cl:9][CH:5]([CH3:6])[CH2:4][CH2:3][CH2:2][C:1]([OH:8])=[O:7]

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 8892Hexanoic AcidHCID 32745N-Chloro-N,N-diisopropylamine

生成物 1

HCID 185416685-Chlorohexanoic acid

実験手順

147 parts by mass of the obtained caproic acid and an equivalent amount of N-chlorodiisopropylamine were added to 1,000 parts by mass of 84% sulfuric acid and were reacted for 5 hours at 25° C. to obtain 177 parts by mass of 5-chlorocaproic acid. Then 177 parts by mass of the 5-chlorocaproic acid were boiled with an aqueous solution of an equivalent amount of sodium hydroxide to obtain 129 parts by mass of δ-caprolactone. The 13C-NMR (100 MHz, CDCl3) of the synthesized δ-caprolactone was measured to obtain the following δvalues: 19.90 ppm, 20.88 ppm, 34.27 ppm, 35.31 ppm, 70.44 ppm and 172.84 ppm.

後処理

  1. customwere reacted for 5 hours at 25° C.

出典と根拠

ORDレコード
ord-6df786e4ea3f49e381faf88dde88d3c1
出典データセット
uspto-grants-2003_05
特許番号
US06559275B2

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