405271-20-7 → 325793-74-6

HRID 411878ノート

反応式

HRID 411878 の反応式
[CH2:1]([O:3][C@@H:4]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16]CC2C=CC=CC=2)=[CH:12][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6])[CH3:2]>CO.[C].[Pd]>[CH2:1]([O:3][C@@H:4]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6])[CH3:2]

参加物

4

反応物 1

HCID 12087759405271-20-72 回

生成物 1

HCID 10176889325793-74-6収率 96%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

A mixture of (S)-methyl 2-ethoxy-3-(4-benzyloxyphenyl)propanoate of the formula (9c) (56 g) in aqueous methanol (300 ml) and slurry of 5% palladium carbon (6 g in 60 ml water) was taken in hydrogenation flask and hydrogenated on Parr shake flask at 60 psi pressure for 6-8 h at room temperature. Completion of the reaction was monitored by TLC. After completion of the reaction, the catalyst was filtered and the filtrate was evaporated to yield tile compound of the formula (1) (39 g, 96%).

後処理

  1. customAfter completion of the reaction
  2. filtrationthe catalyst was filtered
  3. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-ef117fd157c348dda8a35db025a03fec
出典データセット
uspto-grants-2003_05
特許番号
US06559335B2

反応ノート

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