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Chlorotrimethylsilane → Methyl 2,2,4-Trimethyl-3-silyloxypent-3-enecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chlorotrimethylsilane | HCID 6397 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | 2,2,4,4-Tetramethyl-1,3-cyclobutanedione | HCID 13617 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 生成物 | Methyl 2,2,4-Trimethyl-3-silyloxypent-3-enecarboxylate | HCID 123759875 | — |
反応手順
84 g (0.6 mol) of 2,2,4,4-tetramethylcyclobutane-1,3-dione and 32.4 g (0.6 mol) of sodium methylate were mixed together in 320 ml of tetrahydrofuran. 65.1 g (0.6 mol) of trimethylsilyl chloride were added dropwise and the mixture was stirred. The reaction mixture was then concentrated and the residue was taken up with diethyl ether. The solid was filtered off with suction and the mother liquor was concentrated. Yield: 135 g (89%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06559343B1 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-018233e2db2a44b78cd771c96c80a5be |
| 出典メモ | uspto-grants-2003_05 |