1,4-Dioxane hydrochloride → (r)-5,11-Dihydro-5-[1-[2-(4-dimethylaminophenyl)ethyl]-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]oxazepine dihydrochloride
反応式
[ClH:1].O1CCOCC1.[CH3:8][N:9]([CH3:39])[C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][N:18]2[CH2:22][CH2:21][CH2:20][C@@H:19]2[CH2:23][N:24]2[C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=3[CH2:28][O:27][C:26]3[CH:35]=[CH:36][CH:37]=[CH:38][C:25]2=3)=[CH:12][CH:11]=1>ClCCl>[ClH:1].[ClH:1].[CH3:39][N:9]([CH3:8])[C:10]1[CH:11]=[CH:12][C:13]([CH2:16][CH2:17][N:18]2[CH2:22][CH2:21][CH2:20][C@@H:19]2[CH2:23][N:24]2[C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=3[CH2:28][O:27][C:26]3[CH:35]=[CH:36][CH:37]=[CH:38][C:25]2=3)=[CH:14][CH:15]=1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
0.6 ml of 4 M hydrochloride/dioxane was added to a solution of 238 mg of (R)-5,11-dihydro-5-[1-[2-(4-dimethylaminophenyl)ethyl]-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]oxazepine in dichloromethane (10 ml), and the solution was stirred for 5 minutes. The solvent was evaporated under reduced pressure, and the residue was recrystallized from a mixed solvent of ethanol, dimethoxyethane and ether to obtain the title compound in the form of a white solid (204 mg, 73%).