Ethyl 4-isocyanatobenzoate → HCID 9808166、化合物
反応式
[OH:1][CH2:2][C:3]1[N:4]=[CH:5][N:6]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][C:17]=2[C:18]([F:21])([F:20])[F:19])[NH:14][C:13](=[O:22])[C:12]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:11]3)[CH:7]=1.[N:28]([C:31]1[CH:41]=[CH:40][C:34]([C:35]([O:37][CH2:38][CH3:39])=[O:36])=[CH:33][CH:32]=1)=[C:29]=[O:30]>C(OCC)(=O)C>[CH2:38]([O:37][C:35]([C:34]1[CH:40]=[CH:41][C:31]([NH:28][C:29]([O:1][CH2:2][C:3]2[N:4]=[CH:5][N:6]([C:8]3[CH:9]=[C:10]4[C:15](=[CH:16][C:17]=3[C:18]([F:20])([F:21])[F:19])[NH:14][C:13](=[O:22])[C:12]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:11]4)[CH:7]=2)=[O:30])=[CH:32][CH:33]=1)=[O:36])[CH3:39]参加物
4
実験手順
To a suspension of the compound of Example 17 (768 mg, 2.01 mmol) in ethyl acetate (30 ml) was added ethyl 4-isocyanatobenzoate (769 mg, 4.02 mmol), and the mixture was refluxed for 48 hours. After cooling with ice, the precipitated crystals were collected by filtration, washed with ethyl acetate, and then dried under reduced pressure, thereby obtaining 1.13 g of title compound as colorless powder. Yield 98%.