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Aniline → 1-(Phenylamino)butan-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | 1,2-Epoxybutane | HCID 7834 | — |
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | Potassium Fluoride | HCID 522689 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-(Phenylamino)butan-2-ol | HCID 14072197 | — |
反応手順
Aniline, (102.3 g, 1.1 mole) was added to 50 ml of dioxane, 108 g of 1,2-epoxy butane and 1 g of potassium fluoride in 25 ml of water. The mixture heated to reflux for 30 hours. The mixture was poured into water, taken up in 200 ml of methylene chloride, dried over anhydrous magnesium sulfate and stripped under vacuum. The residue was distilled under vacuum and the product, b.p. 98°-106° C. at 0.15 mm, weighed 94 g and was 97% pure by GLPC. It was characterized by IR and NMR.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04723986 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-81dc0c6c46c04f688c9e0a0ed9716418 |
| 出典メモ | uspto-grants-1988_02 |