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3-Chlorobenzaldehyde → 2-m-Chlorophenyl-3-(3-trifluoromethyl-4-fluorophenyl)-5-ethyl oxazolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chlorobenzaldehyde | HCID 11477 | — |
| 反応物 | 1-(3-Trifluoromethyl-4-fluorophenylamino)-2-butanol | HCID 20152671 | — |
| 触媒 | Methanesulfonic Acid | HCID 6395 | — |
| 生成物 | 2-m-Chlorophenyl-3-(3-trifluoromethyl-4-fluorophenyl)-5-ethyl oxazolidine | HCID 20152670 | — |
反応手順
Meta-chlorobenzaldehyde (2.3 g, 0.016 mole) was combined with 5 g of 1-(3-trifluoromethyl-4-fluorophenylamino)-2-butanol and 3 drops of methane sulfonic acid was added. The mixture was heated on the steam bath for about one hour and stripped on the rotary evaporator. The product, a sticky, thick liquid, was characterized by IR and NMR.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04723986 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-2606b9cbf440416d8f3e63a1500dbed7 |
| 出典メモ | uspto-grants-1988_02 |