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Water → 2-m-Cyanophenyl-3-(3-trifluoromethyl-4-chlorophenyl)-5-ethyl oxazolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | m-Formylbenzonitrile | HCID 90670 | — |
| 反応物 | 1-(3-Trifluoromethyl-4-chlorophenylamino)-2-butanol | HCID 20152672 | — |
| 触媒 | Methanesulfonic Acid | HCID 6395 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-m-Cyanophenyl-3-(3-trifluoromethyl-4-chlorophenyl)-5-ethyl oxazolidine | HCID 14072200 | — |
反応手順
Meta-cyanobenzaldehyde (2.1 g, 0.016 mole) was added to 4.3 g of 1-(3-trifluoromethyl-4-chlorophenylamino)-2-butanol in 50 ml of toluene and 2-3 drops of methane sulfonic acid was added. The mixture was refluxed under a modified Dean-Stark apparatus until no more water came off and the mixture was stripped on a rotary evaporator. Yield was 6 g of product, nD30 1.5774. It was characterized by IR and NMR.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04723986 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-95fce6ee0fd6497e86db89788ce9af11 |
| 出典メモ | uspto-grants-1988_02 |