Dichloromethane → 2-Isopropoxyethyl Methanesulfonate
反応式
ClCCl.[CH:4]([O:7][CH2:8][CH2:9][OH:10])([CH3:6])[CH3:5].C(N(CC)CC)C.[CH3:18][S:19](Cl)(=[O:21])=[O:20]>C(OCC)(=O)C.O>[CH3:18][S:19]([O:10][CH2:9][CH2:8][O:7][CH:4]([CH3:6])[CH3:5])(=[O:21])=[O:20]参加物
7
実験手順
To a dichloromethane (50 mL) mixture of 2-isopropoxyethanol (5.21 g, 50.0 mmol) and triethylamine (7.70 mL, 55.0 mmol), was added methanesulfonyl chloride (4.30 mL, 55.0 mmol) while stirring on ice, and the resulting mixture was stirred for 30 minutes. Water and ethyl acetate were added to the mixture. After the mixture was thoroughly shaken, the organic layer was separated, and the organic layer was washed with brine and dried over anhydrous magnesium sulfate. The mixture was filtered, and the solvent in the filtrate was then distilled off under reduced pressure.
後処理
- stirringthe resulting mixture was stirred for 30 minutes
- stirringAfter the mixture was thoroughly shaken
- customthe organic layer was separated
- washthe organic layer was washed with brine
- dry with materialdried over anhydrous magnesium sulfate
- filtrationThe mixture was filtered
- distillationthe solvent in the filtrate was then distilled off under reduced pressure
出典と根拠
- ORDレコード
- ord-2d7de98408074f379c8ba234f78ceff7
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08530504B2
反応ノート
読み込み中…