Dichloromethane → 3-Methoxybutyl methanesulfonate
反応式
ClCCl.[CH3:4][O:5][CH:6]([CH3:10])[CH2:7][CH2:8][OH:9].C(N(CC)CC)C.[CH3:18][S:19](Cl)(=[O:21])=[O:20]>C(OCC)(=O)C.O>[CH3:18][S:19]([O:9][CH2:8][CH2:7][CH:6]([O:5][CH3:4])[CH3:10])(=[O:21])=[O:20]参加物
7
実験手順
To a dichloromethane (30 mL) mixture of 3-methoxy-1-butanol (3.12 g, 30.0 mmol) and triethylamine (4.62 mL, 33.0 mmol), was added methanesulfonyl chloride (4.62 mL, 33.0 mmol) while stirring on ice, and the mixture was stirred at room temperature for 30 minutes. To the mixture, were added water and ethyl acetate. After thoroughly shaking the mixture, the organic layer was separated, and the organic layer was washed with brine and dried over anhydrous magnesium sulfate. The mixture was then filtered, and the solvent in the filtrate was then distilled off under reduced pressure.
後処理
- stirringthe mixture was stirred at room temperature for 30 minutes
- stirringAfter thoroughly shaking the mixture
- customthe organic layer was separated
- washthe organic layer was washed with brine
- dry with materialdried over anhydrous magnesium sulfate
- filtrationThe mixture was then filtered
- distillationthe solvent in the filtrate was then distilled off under reduced pressure
出典と根拠
- ORDレコード
- ord-e0b3177f9ddd4c4a82de19eb17756366
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08530504B2
反応ノート
読み込み中…