Hydrochloric Acid → Efatutazone Dihydrochloride
反応式
[NH2:1][C:2]1[C:34]([CH3:35])=[CH:33][C:5]([O:6][C:7]2[CH:8]=[CH:9][C:10]3[N:14]=[C:13]([CH2:15][O:16][C:17]4[CH:30]=[CH:29][C:20]([CH2:21][CH:22]5[S:26][C:25](=[O:27])[NH:24][C:23]5=[O:28])=[CH:19][CH:18]=4)[N:12]([CH3:31])[C:11]=3[CH:32]=2)=[CH:4][C:3]=1[CH3:36].[ClH:37]>C(OCC)(=O)C>[ClH:37].[ClH:37].[NH2:1][C:2]1[C:3]([CH3:36])=[CH:4][C:5]([O:6][C:7]2[CH:8]=[CH:9][C:10]3[N:14]=[C:13]([CH2:15][O:16][C:17]4[CH:18]=[CH:19][C:20]([CH2:21][CH:22]5[S:26][C:25](=[O:27])[NH:24][C:23]5=[O:28])=[CH:29][CH:30]=4)[N:12]([CH3:31])[C:11]=3[CH:32]=2)=[CH:33][C:34]=1[CH3:35]参加物
4
実験手順
A mixture of 5-[4-[6-(4-amino-3 ,5-dimethylphenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl]thiazolidine-2,4-dione (0.25 g) and 4N hydrogen chloride in ethyl acetate (50 ml) was stirred at room temperature for 24 hours. The insoluble product was filtered and washed with ethyl acetate to afford the desired product (0.25 g, mp 165-175° C.).
後処理
- filtrationThe insoluble product was filtered