化工社化工社 化学情報印刷レポート · 研究参考用
Methyl Benzoate → 3-{4-[3-Biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}-2(R)-hydroxypropionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Benzoate | HCID 7150 | — |
| 反応物 | 1-Biphenyl-2-ylmethanamine | HCID 263366 | — |
| 反応物 | N-chlorocarbamoyl-4-[(4-cyclohexylphenylamino)methyl]benzoic acid methyl ester | HCID 86586062 | — |
| 反応物 | (R)-isoserine ethyl ester hydrochloride | HCID 86586063 | — |
| 生成物 | 3-{4-[3-Biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}-2(R)-hydroxypropionic acid | HCID 10258106 | — |
反応手順
This compound was prepared similarly as described in example 35 from N-chlorocarbamoyl-4-[(4-cyclohexylphenylamino)methyl]benzoic acid methyl ester and biphenyl-2-ylmethylamine followed by hydrolysis of the benzoic acid methyl ester, coupling with (R)-isoserine ethyl ester hydrochloride. Hydrolysis afforded the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06562807B2 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-de5d1ad0dcf94b3684155d7172a7e1b6 |
| 出典メモ | uspto-grants-2003_05 |