1-(Pyridin-4-yl)piperidine-4-carbamic acid benzyl ester → 1-(Pyridin-4-yl)piperidin-4-amine

HRID 412623ノート

反応式

HRID 412623 の反応式
C(OC(=O)[NH:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=2)[CH2:13][CH2:12]1)C1C=CC=CC=1>C(O)C.[C].[Pd]>[NH2:10][CH:11]1[CH2:12][CH2:13][N:14]([C:17]2[CH:18]=[CH:19][N:20]=[CH:21][CH:22]=2)[CH2:15][CH2:16]1

参加物

4

反応物 1

HCID 600641081-(Pyridin-4-yl)piperidine-4-carbamic acid benzyl ester

生成物 1

HCID 189186081-(Pyridin-4-yl)piperidin-4-amine収率 99.9%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

1-(Pyridin-4-yl)piperidine-4-carbamic acid benzyl ester (9.46 g) was hydrogenated using 7.5% palladium carbon (3.57 g) in ethanol (95 ml) solution at 3 atm over 3 hours. After completion of the reaction, the reaction mixture was filtered through celite, and the solvent was evaporated and the residue was dried under reduced pressure to give the title compound (5.38 g).

後処理

  1. customover 3 hours
  2. customAfter completion of the reaction
  3. filtrationthe reaction mixture was filtered through celite
  4. customthe solvent was evaporated
  5. customthe residue was dried under reduced pressure

出典と根拠

ORDレコード
ord-8d081c17604143c885296a33b2179a5f
出典データセット
uspto-grants-2003_05
特許番号
US06562828B1

反応ノート

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