関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Gamma-Aminobutyric Acid | HCID 119 | — |
| 反応物 | Phosphorus trichloride | HCID 24387 | — |
| 反応物 | Phosphorous acid | HCID 107909 | — |
| 生成物 | Alendronic Acid | HCID 2088 | — |
反応手順
The mixture of 5 eq. phosphorous acid, 4-aminobutyric acid and morpholine. HCl is melted together until uniform solution is formed. The reaction mixture is cooled to about 70° C. and 2 eq. of PCl3 are carefully added. The mixture is heated for about 5.5 hours before the reaction mixture is hydrolyzed in aqueous acid at about 80° C. and alendronate is isolated from an ethanolic solution.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06562974B2 |
|---|
| 出典データセット | uspto-grants-2003_05 |
|---|
| ORD ID | ord-b3a0f7fd2bd7403f9357ce99aee0cb71 |
|---|
| 出典メモ | uspto-grants-2003_05 |
|---|
