Ammonia → 2,3,5-Trifluoro-6-nitroaniline

HRID 412726

反応式

HRID 412726 の反応式
F[C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[C:4]([F:10])[C:3]=1[N+:11]([O-:13])=[O:12].[NH3:14].O1CCOCC1>O>[F:8][C:7]1[C:6]([F:9])=[CH:5][C:4]([F:10])=[C:3]([N+:11]([O-:13])=[O:12])[C:2]=1[NH2:14]

参加物

5

反応物 3

HCID 222AmmoniaHCID 312751,4-DioxaneHCID 675661,2,3,5-Tetrafluoro-4-nitrobenzene

生成物 1

HCID 2230852,3,5-Trifluoro-6-nitroaniline収率 51%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution comprising 2,3,4,6-tetrafluoronitrobenzene (0.6 g, 3.1 mmol) and ammonia in dioxane (Aldrich, 0.5M, 7.5 mmol) was stirred at room temperature for 3 hours to give a fine white precipitate. The mixture was diluted with an equal volume of water to dissolve the white precipitate and give yellow crystals. The crystals were isolated were collected and dried to provide 2,3,5-trifluoro-6-nitroaniline (307 mg, 51%) as yellow needles; m.p. 66° C.; 1H NMR (CDCl3) δ 6.4 (1H, m), δ 6.0 (2H, s).

後処理

  1. customto give a fine white precipitate
  2. dissolutionto dissolve the white precipitate
  3. customgive yellow crystals
  4. customThe crystals were isolated
  5. customwere collected
  6. customdried

出典と根拠

ORDレコード
ord-63bd390fc9ae4e0e94c0a4d53118d5a4
出典データセット
uspto-grants-2003_05
特許番号
US06562854B2

関連ノート

読み込み中…